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KMID : 0359920080270030299
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Korean Journal of Nephrology
2008 Volume.27 No. 3 p.299 ~ p.306
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The Relative Risk of Diseases Related to Chronic Kidney Disease according to the Estimated Glomerular Filtration Rate in the Elderly Population
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Han Seung-Seok
Kim Ki-Woong
Chin Ho-Jun
Na Ki-Young
Kim Suhng-Gwon
Chae Dong-Wan
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Abstract
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Purpose: The chronic kidney disease (CKD) is defined as structural or functional abnormalities of the kidney diagnosed by abnormalities of pathology, composition of blood or urine, imaging tests and glomerular filtration rate (GFR) less than 60 mL/min/1.73m2. GFR less than 60 mL/min/1.73m2 is known to increase the number of complications. This guideline is universally used but there are no studies on whether the guideline is applicable to Korean people, especially to elderly population.
Methods: We randomly selected 1,000 subjects aged more than 65 years who lived in Seong-nam city during September, 2005. We used the modified MDRD equation to estimate the glomerular filtration rate (eGFR) and categorized the subjects into 5 groups (group 1: GFR >70, group 2: 60-70, group 3: 50-60, group 4: 40-50, group 5: <40 mL/min/1.73m2).
Results: The mean creatinine level was 1.1 (±0.3) mg/dL and the mean value of eGFR was 60.9 (±12.9) mL/min/1.73m2. The frequency of subjects with eGFR less than 60 mL/min/1.73m2 was 48%. The frequencies of old age, female, hypertension, coronary heart disease, anemia, hypoalbuminemia, proteinuria, and increased waist circumference increased as eGFR fell. When evaluating the odds ratios of complications of CKD (Group 2-5 versus Group 1), the risk of coronary heart disease was increased in Group 3, 4, 5, hypertension in Group 4, 5 and diabetes mellitus, anemia, and proteinuria in Group 5, respectively.
Conclusion: The prevalence of CKD in the elderly population was high. The elderly Koreans with CKD showed increasing comorbidities at a lower GFR.
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KEYWORD
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Chronic renal insufficiency, Aged, Glomerular filtration rate
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